The running joke of Squirrel Girl is her defeat of the most powerful Marvel characters such as Thanos, Dr. Doom, and the Avengers. We don't see how this happens but rather the aftermath when they are laying on the ground defeated. This new series gives her the framework of attending college and a friend in the form of her hipster-ish black roommate. There is also a potential love interest in Chipmunk Hunk, a fellow hero and student at the same college.
I wouldn't mind seeing a Squirrel Girl animated TV show. I feel that this would be the best venue for her rather than a movie or live action TV show as it would allow her to be herself rather than an awkward live construct that would not satisfy the faithful.